You are here: Home / Resources / Browse Resources

Open. Adaptable. Free.

Resources created by our members and partners.

The QUBES platform hosts hundreds of teaching materials, reference materials, and cloud-based software free to use and adapt using open Creative Commons licenses.

Text Search:
Applied Filters
    Using Bioinformatics Activities to understand the Past and Present of SARS-CoV2
    We have designed a Bioinformatics activity that uses tools to identify the origins and mutations in the novel SARS-CoV2 strains.
    1794

    views

    1125

    downloads

    0

    comments

    0

    adaptations

    Creating Phylogenetic Trees from DNA Sequences
    This interactive module shows how DNA sequences can be used to infer evolutionary relationships among organisms and represent them as phylogenetic trees.

    Keywords: EvolutionHHMI BioInteractivephylogenetic tree

    1791

    views

    946

    downloads

    0

    comments

    0

    adaptations

    Cystic Fibrosis Mechanism and Treatment
    This animation shows how mutations in an ion channel protein lead to the genetic disease cystic fibrosis. The animation also discusses how research on this protein has been used to develop...

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymacromoleculesGenetic diseaseCell Structure & Function

    1090

    views

    191

    downloads

    0

    comments

    0

    adaptations

    A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation
    Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is...

    Keywords: mutationProtein Structureethicscentral dogmahuman disease

    2726

    views

    247

    downloads

    0

    comments

    0

    adaptations

    GMC: Genes, Mutations and Cancer - Group Concept Map Development
    It has been shown that active learning strategies used in the classroom can increase student learning and retention of information. We generated an active learning exercise that can be used in the...

    Keywords: mutationcancerCell Division

    2616

    views

    446

    downloads

    0

    comments

    0

    adaptations

    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

    2476

    views

    727

    downloads

    0

    comments

    0

    adaptations

    Exploring the Introduction of Genetic Variation by Random Mutation: Avida-Ed Lab Book Exercise 1
    An introductory activity introducing the role of random mutation in generating genetic variation using the Avida-ED simulation.

    Keywords: geneticsEvolutionavida-edmutationsoftware simulations

    935

    views

    757

    downloads

    0

    comments

    0

    adaptations

    Mutation and Selection: An Exploration of Antibiotic Resistance in Serratia Marcescens
    This laboratory module gives students hands-on experience with mutation and selection in bacteria.

    Keywords: moduleinquiry labsmutationartificial selectionbacteriain-class activityHandoutlab protocolResources @ QUBES - Teaching & Referenceantibiotic-resistance

    1170

    views

    212

    downloads

    0

    comments

    0

    adaptations

    Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology
    The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module,...

    Keywords: mutationtranscriptiongene expressioncentral dogmatranslationgel electrophoresisGenotype/Phenotype

    3199

    views

    213

    downloads

    0

    comments

    0

    adaptations

    Nextstrain adaptations for Understanding COVID-19
    This resource introduces students to the use of Nextstrain and Nextclade to visualize the phylogeny of SARS-CoV-2 variants of concern and variants of interest. Terminology and an introduction to...

    Keywords: uniprotCOVID19SARS-CoV-2NextstrainNextcladeSpike glycoproteinVariants of Concern

    932

    views

    542

    downloads

    0

    comments

    0

    adaptations

    Predicting and classifying effects of insertion and deletion mutations on protein coding regions
    Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of...

    Keywords: mutationcentral dogmatranslationframeshift

    3048

    views

    567

    downloads

    0

    comments

    0

    adaptations

    COVID-19: Molecular Basis Infection Revisited One Year into the Pandemic
    This adaptation was written in Spring 2021 exactly one year after the original case and includes explorations of the emerging mutations within the spike protein

    Keywords: infectionvaccinemolecular visualization and analysisCOVID19PDBSARS-CoVMolecular Case Studyvariantsantibody

    941

    views

    616

    downloads

    0

    comments

    0

    adaptations

    Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
    This lesson is a five-week series of laboratory activities designed to help students transition from applying lower order thinking skills to the central dogma to applying higher-order thinking skills.

    Keywords: bioinformaticsNIBLSEProtein StructureDNAmolecular modelinggenotypephenotypeCourseSourcecomputational modelingcentral dogmaplant leaf structure

    1320

    views

    293

    downloads

    0

    comments

    0

    adaptations

    Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience
    Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience...

    Keywords: EvolutionmutationcompetitionNatural Selectionregulationstructure and functionreproductive fitnessgenotype to phenotypehomologs

    3050

    views

    238

    downloads

    0

    comments

    0

    adaptations

    Using Raw Sequence Data to Analyze Tumor Suppressor Mutations
    Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to...

    Keywords: bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data

    222

    views

    17

    downloads

    0

    comments

    0

    adaptations

    Got Milk? Biome 2021 Lightning Talk
    The Got Milk? working group plans to use lactase persistence evolution as a case study to teach genetics in large introductory biology courses. While developing these resources, we will be mindful...

    Keywords: geneticsintroductory biologyundergraduate researchundergraduate educationStudent misconceptionsbiasdiversitylactase persistenceraceBIOME 2021

    879

    views

    228

    downloads

    0

    comments

    0

    adaptations

    Bioinformatics: the Power of Computers in Biology – a Practical Guide
    This Practical Guide in the Bringing Bioinformatics into the Classroom series introduces simple bioinformatics approaches for database searching and sequence analysis.

    Keywords: NIBLSEGOBLET

    1024

    views

    259

    downloads

    0

    comments

    0

    adaptations

    Exploring Fitness and Population Change under Selection: Avida-Ed Lab Book Exercise 3
    An introductory activity exploring the process of natural selection in action using the Avida-ED simulation.

    Keywords: population geneticsfitnessavida-edsoftware simulationsSelectionevolutionary fitness

    2827

    views

    1779

    downloads

    0

    comments

    0

    adaptations

    Exploring Random Mutation and Selection: Avida-Ed Lab Book Exercise 2
    An introductory activity exploring the role of random mutation in natural selection using the Avida-ED simulation.

    Keywords: avida-edmutationsoftware simulationsSelectionvariation

    889

    views

    763

    downloads

    0

    comments

    0

    adaptations

    Hardy-Weinberg Equilibrium
    This module introduces the Hardy-Weinberg model in the context of understanding the population's genotype and allele frequencies. It is intended for an introductory biology audience.

    Keywords: genotypeallelesGenetics and EvolutionFrequenciesHardy-Weinberg model

    866

    views

    320

    downloads

    0

    comments

    0

    adaptations

    Close

    Home

    Search