"Drug Design" 11 posts Sort by created date Sort by defined ordering View as a grid View as a list
This module introduces rates of reactions in the context of understanding how enzymes affect chemical reactions. It is intended for an introductory biology audience.
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Rob Levenson onto Drug Design @ 7:58 pm on 24 Aug 2022
This module introduces the Scatchard equation in the context of understanding antigen binding and the properties of antigens. It is intended for an introductory biology audience.
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This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.
Rob Levenson onto Drug Design @ 7:53 pm on 24 Aug 2022
This tutorial provides an overview of the immune system, concentrating on the roles played by B and T lymphocytes, and on the antigen-presentation system.
This case focuses on understanding structure and function relationships in Piwi, a protein that is critical for germline stem cell function and development of eggs in the fruit fly ovary.
Rob Levenson onto Drug Design @ 7:46 pm on 24 Aug 2022
This case study leads students through the process of proposing a drug for a novel protein. The Mpro protease of SARS-CoV-2 is explored in detail within the PDB. Aligns with first semester biochemistry objectives.
Rob Levenson onto Drug Design @ 7:45 pm on 24 Aug 2022
Students use published scientific data to determine which types of nanoparticles would be best to use to deliver cytotoxic drugs directly to cancer cells. Then they learn about the scientist who generated the data.
Rob Levenson onto Drug Design @ 7:23 pm on 24 Aug 2022
This case focuses on understanding the molecular basis of Anna's sleeping disorder and its treatment. The adaptations addressed question clarity and reformatting to use Mol*.
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Rob Levenson onto Drug Design @ 7:20 pm on 24 Aug 2022
Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
Rob Levenson onto Drug Design @ 5:40 pm on 24 Aug 2022
We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the drug.
pharmacokinetics modeling
Rob Levenson onto Drug Design @ 5:39 pm on 24 Aug 2022