Spider Silk: Stress-Strain Curves and Young's Modulus

This module introduces the stress-strain curve in the context of understanding materials' mechanical behavior. It is intended for an introductory biology audience.

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Enzymes and the Rate of Chemical Reactions

This module introduces rates of reactions in the context of understanding how enzymes affect chemical reactions. It is intended for an introductory biology audience.

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Antibody Binding

This module introduces the Scatchard equation in the context of understanding antigen binding and the properties of antigens. It is intended for an introductory biology audience.

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Growth Mindset Prompt

Before giving an introduction to growth mindset, these prompts can be given to students so they can brainstorm activities they associate with long hours of practice (growth mindset) vs. natural talent (fixed mindset). Developed by Arietta Fleming-Davies.

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The p53 Gene and Cancer

This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

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Cells of the Immune System

This tutorial provides an overview of the immune system, concentrating on the roles played by B and T lymphocytes, and on the antigen-presentation system.

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Modeling the lac Operon to Understand the Regulation of Gene Expression in Prokaryotes

This resource is a recitation activity designed for an introductory biology course in which students explore a lac operon simulation (https://qubeshub.org/resources/phetlacoperon).

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Gelin’: Gel Electrophoresis Simulation

Students will understand how DNA is separated into a fingerprint by using a chromatography activity to simulate gel electrophoresis.

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Intro videos and terminology for GMOs, Transcription, Translation

Compiled resources around GMOs and protein production including vocabulary, animations, videos, and games

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Bacteria Transformation

TeachEngineering resource in which students construct paper recombinant plasmids to simulate the methods genetic engineers use to create modified bacteria.

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Piwi Matters

This case focuses on understanding structure and function relationships in Piwi, a protein that is critical for germline stem cell function and development of eggs in the fruit fly ovary.

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Drugging SARS-CoV-2

This case study leads students through the process of proposing a drug for a novel protein. The Mpro protease of SARS-CoV-2 is explored in detail within the PDB. Aligns with first semester biochemistry objectives.

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CRISPR Gene Editing: Designing the gRNA and Donor Template

In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the case study, Piwi Matter, or designed by the instructor.

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Conservation and ethics of using synthetic genetics

This contains teaching material - powerpoints and handouts that can be adapted for lectures and/or discussion groups.

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Using Nanoparticles to Treat Cancer Scientist Spotlight

Students use published scientific data to determine which types of nanoparticles would be best to use to deliver cytotoxic drugs directly to cancer cells. Then they learn about the scientist who generated the data.

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Waking up Anna - Adaptations and Conversion to Mol*

This case focuses on understanding the molecular basis of Anna's sleeping disorder and its treatment. The adaptations addressed question clarity and reformatting to use Mol*.

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The Ames Test

Introduction to the Ames Test, published as GSA Learning Resource

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Bioinformatics: Food Detective – a Practical Guide

This Practical Guide in the Bringing Bioinformatics into the Classroom series introduces the idea of computers as tools to help understand aspects of biology.

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Does it pose a threat? Investigating the impact of Bt corn on monarch butterflies

primary literature discussion of Bt corn effects

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Using Undergraduate Molecular Biology Labs to Discover Targets of miRNAs in Humans

Incorporating authentic research experiences into undergraduate labs, while shown to be particularly effective at engaging and retaining students in STEM majors, can be difficult to accomplish within the constraints of resource availability or cost, and time limitations. One area that is particularly amenable to adaptation for undergraduate lab classes is the discovery and validation of targets of microRNAs (miRs). The human genome encodes several hundred, possibly several thousand miRs, each of which is a 22 nucleotide long RNA molecule capable of regulating the expression of multiple target genes. miRs have been shown to be critical during development, for human health and disease, and are currently being investigated as both therapeutic agents, as well as possible drug targets. A lack in understanding the mechanisms by which miRs recognize their targets makes computer-based predictions of miR targets quite inaccurate, necessitating experimental verification of such predictions. In this lesson, we describe an easily adaptable lab module that can be used in existing undergraduate molecular biology lab courses to conduct authentic scientific research. Students use a variety of databases to identify likely candidate genes whose expression may be altered by a given miR, and then experimentally test their predictions in human cells. This inquiry-based module gives students a taste of real scientific research and excites them about the possibility that, even as a student, they have the potential to contribute to this cutting edge research.

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