"Drug Design" 11 posts Sort by created date Sort by defined ordering View as a grid View as a list

Enzymes and the Rate of Chemical Reactions

This module introduces rates of reactions in the context of understanding how enzymes affect chemical reactions. It is intended for an introductory biology audience.

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Antibody Binding

This module introduces the Scatchard equation in the context of understanding antigen binding and the properties of antigens. It is intended for an introductory biology audience.

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The p53 Gene and Cancer

This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

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Cells of the Immune System

This tutorial provides an overview of the immune system, concentrating on the roles played by B and T lymphocytes, and on the antigen-presentation system.

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Piwi Matters

This case focuses on understanding structure and function relationships in Piwi, a protein that is critical for germline stem cell function and development of eggs in the fruit fly ovary.

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Drugging SARS-CoV-2

This case study leads students through the process of proposing a drug for a novel protein. The Mpro protease of SARS-CoV-2 is explored in detail within the PDB. Aligns with first semester biochemistry objectives.

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Using Nanoparticles to Treat Cancer Scientist Spotlight

Students use published scientific data to determine which types of nanoparticles would be best to use to deliver cytotoxic drugs directly to cancer cells. Then they learn about the scientist who generated the data.

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Waking up Anna - Adaptations and Conversion to Mol*

This case focuses on understanding the molecular basis of Anna's sleeping disorder and its treatment. The adaptations addressed question clarity and reformatting to use Mol*.

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5-012-LipoproteinModeling-ModelingScenario

Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.

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5-011-ModelingIbuprofren-ModelingScenario

We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the drug.

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1-132-DigoxinElimination-ModelingScenario

pharmacokinetics modeling

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