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    COVID-19: On the way to a vaccine
    This multi-part case study introduces the reader to the SARS-CoV-2 virus origins, the molecular basis of the infection, the development and severity of symptoms, and treatment.

    Keywords: BLASTprotein structure modelingmolecular visualization and analysisCOVID19PDB

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    Understanding COVID-19 Biology to Design a Vaccine
    This multi-part case study introduces the reader to the SARS-CoV-2 virus, replication, and treatment. Additional worksheets introduce students to bioinformatics tools of 3-D protein visualization...

    Keywords: BLASTprotein structure modelingmolecular visualization and analysisCOVID19PDB

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    Understanding COVID-19 Biology to Design a Vaccine - Ethics supplement
    The adaptation to Understanding COVID-19 Biology to Design a Vaccine entails two ethics supplements. The first supplement addresses the use of off-label drugs in the pandemic (or other situation)....

    Keywords: bioethicsBLASTprotein structure modelingmolecular visualization and analysisethicsCOVID19PDB

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    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

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    Molecular CaseNet - Developing Intro Tutorials - YouTube
    Biome Institute 2020, Summary Video

    Keywords: introductory biologyMolecular structuremolecular visualizationMolecular Case Study

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    Ecology/Environmental Biology Molecular Case Studies for Molecular CaseNet - YouTube
    Biome Institute 2021, Fall Working Group Summary Video

    Keywords: climate changebiofilmcoffeecoral bleachingMolecular structuremolecular visualizationMolecular Case Studycholera

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    A "Box of Lessons" for Exploring Biomolecular Structure and Function
    Biomolecular structure and function is emphasized as a core concept in a variety of community determined educational standards for biology and chemistry. Most curricula introduce students to the...

    Keywords: bioinformaticsproteinsRNADNAmolecular visualizationbiomolecular structurebiomolecular visualizationProtein Data BankPDBMolecular CaseNet FMN

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    Phylogenetic analysis using collections material: interpreting trait evolution by comparison of morphological and molecular genetic hypotheses
    Exercise spans two weeks, includes homework, and involves some groups of animals as well as plants. Emphasizes re-interpretation of morphological trait evolution following molecular genetic...

    Keywords: Evolutionmorphologyphylogenylaboratoryplantsbiological collectionsmolecular analysis

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    Learn Biological Sciences and Physics through scientific process, creation, experimentation and analysis
    Microbes remain attached and grow on various surfaces whether living or non-living. These surfaces provide differential growth substances for microbes to remain attached or grow. The differential...

    Keywords: data analysisscientific methodphysicshands-onScientific InquirymicrobesBiological SciencesSpectrophotometer

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    The Human Microbiome Biodiversity in Health and Disease
    The students will analyze the human gut and vaginal microbiomes in healthy and diseased states using diversity of bacteria as determined by 16SrRNA sequence.
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    Remote sensing data processing – NEON airborne data
    Concepts of remote sensing and data logistics, and NEON remote sensing data are introduced. Students learn how to apply spatial data processing and visualization skills using R coding program to...

    Keywords: RlandscapebiomassProblem Solvingraster raster data processingspatial data visualizationvegetation indicescanopy

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    Module 6: Alternative Splicing
    This module explores how multiple different mRNAs and polypeptides can be encoded by the same gene. After completing this module students will be able to explain how alternative splicing of a gene...

    Keywords: geneticsdata visualizationmolecular biologygenomicsexonintronalternative splicingSimilarity searchesMessenger RNA

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    Phylogeny of Land Plants
    In this lab, students review the characteristics of the major land plant lineages. Then they perform phylogenetic analyses based on morphological characters.

    Keywords: morphologyphylogenylaboratoryplantsmolecular analysis

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    3D breast cancer tissue reconstruction
    This module allows students to follow a researcher as she discovers new features of breast cancer tissue architecture, using 3D reconstructions of histological specimens.

    Keywords: graphingdata visualizationbreast cancerDCIShistogramscentroidsums of squares

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    Module 4: Removal of Introns from pre-mRNA by Splicing
    In this module, students will learn to identify splice donor and acceptor sites that are best supported by RNA-Seq data, and use the canonical splice donor and splice acceptor sequences to identify...

    Keywords: geneticsdata visualizationmolecular biologygenomicsexonintronsplicingSimilarity searchesRNA Maturation

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    Yeti or not: Do they exist?
    Through this 4-part bioinformatics case study, students will be led through the forensic analysis of putative Yeti artifacts based on published findings.

    Keywords: case studybioinformaticsNIBLSEBLAST12S sequencingYeti

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    DCS 105 Calling Bull F24 Schedule
    Schedule overview for Bates College Course DCS 105 Calling Bull

    Keywords: datacalling bullmisinformationBates CollegeSchedule

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    Module 2: Transcription Part I: From DNA Sequence to Transcription Unit
    This module illustrates how a primary transcript (pre-mRNA) is synthesized using a DNA molecule as the template. Students will learn about the importance of the 5' and 3' regions of the gene for...

    Keywords: data visualizationmolecular biologybioinformaticsGenome BrowsergenomicsTranscription InitiationTranscription Start SiteTranscription Termination Signal

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    Data Analysis and Cancer
    This is a flipped classroom approach, students will learn the basic content about cell-signaling, p53, and transcription factors before class. During class students will focus on data analysis...

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologydata interpretationBiological Data Analysiscell cyclemacromoleculesGenetic diseaseCell signaling

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    Phenotypic plasticity and predation
    Students predict changes to tadpole morphology and coloration after considering characteristics of the predator species and the prey themselves then test their own hypotheses (typically with...

    Keywords: RExcelimage analysisgraphingt-testsfrequency histogramsdata visualizationANOVAhypothesis formulationpredator-prey interactionsphenotypic plasticity

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