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    Case Study — World records as measures of senescence or randomness
    This is a project meant to accompany the Case Study that Carl Bergstrom, which uses R to explore whether declining track and field world record performance could be an artifact of sample size (less...

    Keywords: RRStudioprogrammingsampling distributionProbability & Statisticsrandomnesscontinuous probability distribution

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    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

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    Competition under the Sea: Exploring the competitive interaction between native and non-native seagrasses in the Caribbean
    A mini-case study that uses real-world data to explore the competitive interaction among seagrasses.

    Keywords: ecologycompetitionconservation ecologywater resource managementseagrassCaribbean

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    How Many More Thymes & Herbivore Defense
    Adaptations to the How Many More Thymes? case study featuring terpene-based herbivore defense and pollinator attraction in Nicotiana plants.

    Keywords: food websgenotypephenotypeHerbivoryherbivoredeterrencemonoterpeneproducerchemotypeThymus vulgaristhymeMediterranean ecosystemchemical defensesManduca sextaNicotiana

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    Bacteria to Brains in Backyard Coyotes: An Interdisciplinary Pedagogical Case Study
    Our interdisciplinary pedagogical case study explores the differences between rural and urban coyotes at the levels of organismal and community ecology. The focus is on how coyotes’ gut microbiomes...

    Keywords: Vision and Changeecologyintroductory biologyImmunologymicrobiologydietanimal behaviormicrobiomecore conceptscoyotesBraingut-brain axisImmunoReachcytokinedysbiosis

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    COVID-19: Molecular Basis of Infection-ADAPTATION
    This case was written in Spring 2020 during the COVID-19 pandemic. It focuses on understanding the structure and interaction of the SARS-Cov-2 viral spike protein that facilitates infection in...

    Keywords: infectionvaccinemolecular visualization and analysisCOVID19PDBSARS-CoVMolecular Case Study

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    Case Study: Pollination of the Early Spider Orchid (Ophrys sphegodes) by the Solitary Bee (Andrena nigroaenea)
    The research uses natural history collection data to explore a potential phenological shift between an orchid that employs sexual deception and a solitary bee.

    Keywords: pollination biologyClimate change and phenologydigitized natural history collectionsPseudocopulation

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    Adaptation of Terrestrial Trophic Cascades & Population Structure to a Non-Major’s Ecology Course
    In this activity, students will use data from natural parks to examine trophic cascades.

    Keywords: case studyBiodiversityplantsResource Typetrophic cascadesnational parks

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    COVID-19: Molecular Basis Infection Revisited One Year into the Pandemic
    This adaptation was written in Spring 2021 exactly one year after the original case and includes explorations of the emerging mutations within the spike protein

    Keywords: infectionvaccinemolecular visualization and analysisCOVID19PDBSARS-CoVMolecular Case Studyvariantsantibody

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    Advanced Student Molecular Case Study Authorship Scaffolded Project and Rubric
    Instructions, assignment prompts, and a rubric for assessing advanced undergraduate authorship of molecular case studies
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    Traditional Ecological Knowledge and Natural History
    In this module, students will explore Western Science and Traditional Ecological Knowledge and review a case study of how the TEK of the Inuit provided a way of knowing and understanding the...

    Keywords: Traditional ecological knowledgeUnderstanding ScienceBowhead Whale

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    COVID-19: On the way to a vaccine
    This multi-part case study introduces the reader to the SARS-CoV-2 virus origins, the molecular basis of the infection, the development and severity of symptoms, and treatment.

    Keywords: BLASTprotein structure modelingmolecular visualization and analysisCOVID19PDB

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    Understanding COVID-19 Biology to Design a Vaccine
    This multi-part case study introduces the reader to the SARS-CoV-2 virus, replication, and treatment. Additional worksheets introduce students to bioinformatics tools of 3-D protein visualization...

    Keywords: BLASTprotein structure modelingmolecular visualization and analysisCOVID19PDB

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    Coyote Habituation and a Scientist Spotlight on Dr. Christopher Schell
    Dr. Christopher Schell is an ecologist who uses a variety of techniques to study mammalian carnivores in urban areas. This scientist spotlight uses graphs from his study on parental habituation to...

    Keywords: conservation ecologyanimal behaviorurban ecologyInterpreting GraphsBLACK SCIENTISTS IN STEMcoyotes

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    Sickle Cell Anemia using Nicholas’ Story
    The goal of this exercise is to introduce students to 3-D structures of biological molecules, visualize and manipulate them to understand their functions. The exercise also helps them see the...

    Keywords: Hemoglobinsickle cell diseaseMolecular Case Study

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    Hemoglobin cooperativity and adaptations to high altitude living
    This resource accompanies the "How does blood carry oxygen?" chapter in the Integrating Concepts in Biology etext. Students evaluate the cooperativity of hemoglobin and adaptations to high...

    Keywords: Integrating Concepts in Biology

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    Making Predictions with Linear Models: A Murder Mystery Case Study
    This Swirl lesson will introduce two main concepts to students: 1) the idea of uncertainty around linear slopes versus individual values and 2) predicting values using linear models.

    Keywords: data visualizationlinear modelscase study teachinguncertaintypredictionConfidence intervals

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    Calculating Lifetime Cancer Risk Resulting from DNA Replication
    An expanded case study adapted from an HHMI Data Point on Cell Division and Cancer Risk using Figure 1 from Tomasetti, C. and Vogelstein, B. (2015).

    Keywords: cancerScientific ProcessStatistics and MathScientific Methodologybiology of cellscell growth and divisionHigh School

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    Molecular Basis of Sickle Cell Disease
    This multi part case on hemoglobin structure as it relates to oxygen binding and sickle cell disease focuses on utilizing bioinformatics and molecular visualization tools to learn about the sickle...

    Keywords: Hemoglobinmolecular visualization and analysisintroductory bioinformaticssickle cell diseasePDBMolecular Case Studyoxygen bindingmyoglobinmolecular literacy3D protein structuresstructural representations

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    Hypoxia: A Case Study in R
    Aquatic ecosystems are home to a complex intersection of physical and biological factors and an intersection of natural and anthropogenic factors. In the Chesapeake Bay, low oxygen events have...

    Keywords: data analysisOceanographyProject EDDIE

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