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Tags: C4. Bioinformatics tools

Description

C4. Use bioinformatics tools to examine complex biological problems in evolution, information flow, and other important areas of biology. This competency is written broadly so as to encompass a variety of problems that can be addressed using bioinformatics tools, such as understanding the evolutionary underpinnings of sequence comparison and homology detection; distinguishing between genomic sequences, RNA sequences, and protein sequences; and 
23 interpreting phylogenetic trees. “Complex” biological problems require that students should be able to work through a problem with multiple steps, not just perform isolated tasks. 

  • Using multiple lines of evidence, annotate a gene.
  • Develop and interpret a “tree of life” based on a BLAST search, multiple alignment, and
    phylogenetic-tree building.
  • Explain how a mutation in a gene causes cancer, using a genome browser to identify the gene, transcript, and affected protein, and tools such as OMIM, GO, and KEGG to place it in the context of a function and pathway important to the disease.

All Categories (1-20 of 30)

  1. Using Synthetic Biology to Teach Data Science

    26 Jun 2019 | Teaching Materials | Contributor(s):

    By Margaret S Saha1, Beteel Abu-Ageel1, Sanjana Challa1, Xiangyi Fang1, Chai Hibbert1, Anna Isler1, Elias Nafziger1, Adam Oliver1, Hanqiu Peng1, Julia Urban1, Vivian Zhu1

    College of William and Mary

    Abstract for poster on using synthetic biology to introduce students to meaningful data mining, analysis, and application to engineering novel biological constructs.

    https://qubeshub.org/qubesresources/publications/1326/?v=1

  2. A Fun Introductory Command Line Exercise: Next Generation Sequencing Quality Analysis with Emoji!

    07 Jun 2019 | Teaching Materials | Contributor(s):

    By Rachael St. Jacques1, Max Maza1, Sabrina Robertson2, Guoqing Lu3, Andrew Lonsdale4, Ray A Enke5

    1. Department of Biology, James Madison University 2. Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill 3. Department of Biology and School of Interdisciplinary Informatics, University of Nebraska Omaha 4. ARC Centre of Excellence in Plant Cell Walls, Melbourne University 5. James Madison University

    This resource is a fun computer-based intro to command line programming. The activity takes FASTQ NGS data files and runs a fun program called FASTQE.

    https://qubeshub.org/qubesresources/publications/1092/?v=2

  3. Bioinformatics: Investigating Sequence Similarity - A Plant Biology Approach

    29 May 2019 | Teaching Materials | Contributor(s):

    By Ami Erickson

    This laboratory module is a modification of the original published on CourseSource with a focus on plant biology. In the final activity, students conduct a BLAST to compare histone protein...

    https://qubeshub.org/qubesresources/publications/1247/?v=1

  4. Sequence Similarity Resource Adaptation: Exploring Ebola Virus

    16 May 2019 | Teaching Materials | Contributor(s):

    By William Tapprich

    University of Nebraska-Omaha

    This adaptation of the sequence similarity resource provides biology students with a basic set of bioinformatics concepts and tools. These concepts and tools are used to explore relationships...

    https://qubeshub.org/qubesresources/publications/1219/?v=1

  5. Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses

    02 May 2019 | Teaching Materials | Contributor(s):

    By Adam Kleinschmit1, Benita Brink1, Steven Roof2, Carlos Christopher Goller3, Sabrina Robertson3

    1. Adams State University 2. Fairmont State University 3. North Carolina State University

    This laboratory module, published on CourseSource, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.

    https://qubeshub.org/qubesresources/publications/56/?v=5

  6. A Fun Introductory Command Line Exercise: Next Generation Sequencing Quality Analysis with Emoji!

    28 Feb 2019 | Teaching Materials | Contributor(s):

    By Rachael St. Jacques1, Max Maza1, Sabrina Robertson2, Guoqing Lu3, Andrew Lonsdale4, Ray A Enke5

    1. Department of Biology, James Madison University 2. Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill 3. Department of Biology and School of Interdisciplinary Informatics, University of Nebraska Omaha 4. ARC Centre of Excellence in Plant Cell Walls, Melbourne University 5. James Madison University

    This resource is a fun computer-based intro to command line programming. The activity takes FASTQ NGS data files and runs a fun program called FASTQE.

    https://qubeshub.org/qubesresources/publications/1092/?v=1

  7. Using Undergraduate Molecular Biology Labs to Discover Targets of miRNAs in Humans

    04 Jan 2019 | Teaching Materials | Contributor(s):

    By Adam Idica1, Jordan Thompson1, Irene Munk Pedersen1, Pavan Kadandale1

    University of California, Irvine

    In this lesson, we describe an easily adaptable lab module that can be used in existing undergraduate molecular biology lab courses to conduct authentic scientific research, published in CourseSource

    https://qubeshub.org/qubesresources/publications/1007/?v=1

  8. Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes

    04 Jan 2019 | Teaching Materials | Contributor(s):

    By Tara Phelps-Durr

    Radford University

    This lesson is a five-week series of laboratory activities designed to help students transition from applying lower order thinking skills to the central dogma to applying higher-order thinking skills.

    https://qubeshub.org/qubesresources/publications/1006/?v=1

  9. Teaching RNAseq at Undergraduate Institutions: A tutorial and R package from the Genome Consortium for Active Teaching

    04 Jan 2019 | Teaching Materials | Contributor(s):

    By Mark Phillip Peterson1, Jacob T Malloy2, Vincent P Buonaccorsi2, James H Marden3

    1. Viterbo University 2. Juniata College 3. Pennsylvania State University

    This lesson plan was created to teach RNAseq analysis as a part of GCAT-SEEK network. It is provided here, both in finished form and with the modifiable source code, to allow flexible adaptation to...

    https://qubeshub.org/qubesresources/publications/1005/?v=1

  10. Murder by HIV? Undergraduate edition

    04 Jan 2019 | Teaching Materials | Contributor(s):

    By Naowarat (Ann) Cheeptham1, Laura B. Regassa2, Michèle I. Shuster3

    1. Thompson Rivers University 2. Georgia Southern University 3. New Mexico State University

    Bioinformatics case study focusing on phylogenetic tree interpretation, published in the National Center for Case Study Teaching in Science

    https://qubeshub.org/qubesresources/publications/1004/?v=1

  11. Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches

    04 Jan 2019 | Teaching Materials | Contributor(s):

    By Kelsey Metzger

    University of Minnesota, Rochester

    In this four- part guided activity, students will learn about the structure and function of human autosomal and sex chromosomes, view and interpret gene maps, and gain familiarity with basic...

    https://qubeshub.org/qubesresources/publications/1000/?v=1

  12. Finding Selection in All the Right Places

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By Juliet F. K. Noor, Mohamed A. F. Noor

    Lab introducing students to evolutionary genetics using bioinformatics and biocuration, published as GSA Learning Resource

    https://qubeshub.org/qubesresources/publications/994/?v=1

  13. Colon Cancer: A Case of Genetic Bad Luck

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By Anne M. Casper

    Eastern Michigan University

    Case study developed for an introductory genetics class published in the National Center for Case Study Teaching in Science

    https://qubeshub.org/qubesresources/publications/992/?v=1

  14. Bioinformatics / Neuroinformatics

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By William Grisham

    University of California, Los Angeles

    This module is a computer-based introduction to bioinformatics resources. This easy-to-adopt module weaves together several important bioinformatic tools so students can grasp how each is used in...

    https://qubeshub.org/qubesresources/publications/990/?v=1

  15. Bioinformatics: An Interactive Introduction to NCBI

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By Seth Bordenstein

    Marine Biological Laboratory

    Modules showing how the NCBI database classifies and organizes information on DNA sequences, evolutionary relationships, and scientific publications. And a module working to identify a nucleotide...

    https://qubeshub.org/qubesresources/publications/989/?v=1

  16. Behavioral Genetics: Investigating the genes of a complex phenotype in fruit flies

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By Craig E. Stanley, Jr., Charles Hadley S. King, IV, Michelle Thornton, Rob J. Kulathinal

    Introductory genetics laboratory published as GSA Learning Resource

    https://qubeshub.org/qubesresources/publications/988/?v=1

  17. The Ames Test

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By Nathan Goodson-Gregg, Elizabeth A. De Stasio

    Introduction to the Ames Test, published as GSA Learning Resource

    https://qubeshub.org/qubesresources/publications/987/?v=1

  18. Bioinformatics - Investigating Sequence Similarity

    04 Dec 2018 | Teaching Materials | Contributor(s):

    By Adam Kleinschmit1, Benita Brink1, Steven Roof2, Carlos Christopher Goller3, Sabrina Robertson3

    1. Adams State University 2. Fairmont State University 3. North Carolina State University

    This laboratory module, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.

    https://qubeshub.org/qubesresources/publications/56/?v=4

  19. Complete Set of Lessons

    01 Nov 2018 | Teaching Materials | Contributor(s):

    By Anne Rosenwald1, Gaurav Arora2, Vinayak Mathur3

    1. Georgetown University 2. Gallaudet University 3. Cabrini University

    The Genome Solver Project began as a way to teach faculty some basic skills in bioinformatics - no coding or scripting. These Lessons also work well in the undergraduate classroom, culminating with...

    https://qubeshub.org/qubesresources/publications/860/?v=1

  20. BSL-4: Authorized Personnel Only

    24 Sep 2018 | Teaching Materials | Contributor(s):

    By Nicole Anthony

    Biological Sciences, Toronto District School Board

    National Center for Case Study Teaching in Science resource on the 2014 Ebola epidemic. This resource is also included in the NIBLSE Learning Resource Collection

    https://qubeshub.org/qubesresources/publications/795/?v=1