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    Analysis of Amylase Activity
    This lab is an exploration of enzyme function and the effects of environmental conditions on the activity of the enzyme amylase. The lab utilizes analytical and graphing skills to assess enzyme...

    Keywords: data analysisintroductory biologyconcentrationgraphinglinear equationsBiochemistryscientific methodstandard curveenzyme functionMicrosoft ExcelInterpreting GraphsenzymesqbccCreate graphsInterpret graphsSolving Equations and Inequalitiesinterpret tablesAmylaseAlpha-amylaseEnzyme activityMaltoseDNS assayAbsorbancelab reportspectrophotometryregression linemanipulating equationsline of best fitgraphing by hand

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    Collaborative case writing and field testing with Molecular CaseNet brings together discipline specific expertise for innovative pedagogical tools in the classroom
    Molecular case studies (MCS) use an interesting story as a hook , followed by exploration of biochemistry of one or more molecules of interest.  They can be useful in teaching about macromolecule...
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    Nature’s Flying Machines: The Evolutionary Relationship of Avian Form & Function
    In this series of activities, birds will be used as the model organism. The modules examine the connections between body form and function over time by investigating the relationship between avian...

    Keywords: evolutionary ecologyCommunity Ecology

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    Louse Genetics, Genomics, and Gene Function...Oh My!
    In this module, students will be investigating a louse gene with an unknown function to determine if it might be important in the evolution of the louse ecomorphs.

    Keywords: parasitesgenomicsgene sequence analysisFunctional Genomics

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    Drugging SARS-CoV-2
    This case study leads students through the process of proposing a drug for a novel protein. The Mpro protease of SARS-CoV-2 is explored in detail within the PDB. Aligns with first semester...

    Keywords: viruscoronavirusPDBSARS-CoV-2proteasedrug design

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    Exploring the evolution of caffeine biosynthesis enzymes
    Caffeine is a very common stimulant consume worldwide as tea, coffee, mate, cocoa, and chocolate. Ever wondered why plants make caffeine? Do all caffeine producing plants have the same enzymes for...

    Keywords: Bioinformatics EducationBioinformatics and Genomics

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    Venom: To Kill or Cure?
    In this case study, students will explore concepts of evolution, protein structure and function, taxonomy, and methods of scientific inquiry in a real-world way.

    Keywords: EvolutionphylogeneticsidigbioAP Biologytaxonomynatural history collections3D modelsoVertVenomsnakesherps

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    Computational Biology using R
    This is an introductory level course on computational biology.

    Keywords: simulationmoduleRcourseprojectsolutions

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    Movement: Nature's Flying Machines (Online)
    Adapted for online learning: In this lab, you will explore the physics of flight, the adaptations that make powered flight possible, and the evolution of powered flight in vertebrates and...

    Keywords: citizen sciencequantitative skillsDigital RepositoryFlight

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    Curvature and Maximum Permissible Speeds
    In this activity students will compute the curvature of a section of commuter rail and use it to determine a safe speed at which a train should can round the corner without tipping or derailing....

    Keywords: data analysiscalculusnumerical approximationengineeringcalculus 3transportation

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    Birds and Lice: Reciprocal Natural Selection
    This exercise investigates the form and function of lice and their relationship to their bird host.

    Keywords: BiodiversityparasitesbirdsCoevolutionnatural history collections

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    Cystic Fibrosis Mechanism and Treatment
    This animation shows how mutations in an ion channel protein lead to the genetic disease cystic fibrosis. The animation also discusses how research on this protein has been used to develop...

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymacromoleculesGenetic diseaseCell Structure & Function

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    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

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    Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches
    In this four- part guided activity, students will learn about the structure and function of human autosomal and sex chromosomes, view and interpret gene maps, and gain familiarity with basic...

    Keywords: bioinformaticsNIBLSECourseSourceautosomehomologous chromosomeshomologous recombinationsex chromosomesex determinationsex reversal mutations

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    Will You Find This Humerus? Homology Lab
    Students will compare and contrast the morphology of vertebrate forelimbs, and will use this knowledge to draw conclusions about their common ancestor and descent with modification.

    Keywords: Evolutionbiologyidigbionatural history collections3D modelsVertebrate MorphologyoVerthomologous structuresWWISE

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    Advanced Student Molecular Case Study Authorship Scaffolded Project and Rubric
    Instructions, assignment prompts, and a rubric for assessing advanced undergraduate authorship of molecular case studies
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    Case Study: Pollination of the Early Spider Orchid (Ophrys sphegodes) by the Solitary Bee (Andrena nigroaenea)
    The research uses natural history collection data to explore a potential phenological shift between an orchid that employs sexual deception and a solitary bee.

    Keywords: pollination biologyClimate change and phenologydigitized natural history collectionsPseudocopulation

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    Introduction to Genome Annotation
    This exercise is an adaptation of the Annotation Lesson by Rosenwald et al. It introduces the use of bioinformatics tools to extract information from genome databases. It is a basic lesson on...

    Keywords: microbiologyGenome annotationBioinformatics EducationBioinformatics and Genomics

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    The p53 Gene and Cancer
    This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologymacromoleculesGenetic disease

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    Linear Regression (Excel) and Cellular Respiration for Biology, Chemistry and Mathematics
    Students typically find linear regression analysis of data sets in a biology classroom challenging. These activities could be used in a Biology, Chemistry, Mathematics, or Statistics course. The...

    Keywords: statisticsmathematicsdata analysisdatalinear regressionbiologyonlinegraphinglinear equationsQuantitative reasoningassessmentcollege algebracellstatistical analysisregressionOERAlgebrachemistryModelscorrelationSimple Linear RegressionMicrosoft Excellab activityexperimentCellular ProcessesATPqbccUsing Excelmanipulate equationsCellular and Molecular BiologyConcepts in Statisticsoxidationline of best fitexplaining statisticsusing statisticsCellular RespirationPredictionsRespirationgraphing in ExcelLinear CorrelationExothermic Reactioncreate scatter plotAdenosine Triphosphate (ATP)germinating peasPre-lab activityStudent activityHybridCollecting DataR-squareRegression ModelFunctionDependent VariablesIndependent VariablesLinear EquationLinear Equation in two variablescreate graphcreate equationcreate regressioncreate plotinterpret regressioninterpret data

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