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    Regulation of Gene Expression and Adipogenesis by PPAR-γ
    Students learn about transcriptional regulation of PPAR-γ, an important controller of adipose tissue stores and energy metabolism through a drawing/coloring activity of the different components...

    Keywords: gene expressionsmall group worktranscriptional regulationadipose tissuefat metabolismrepressor

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    Instructor Guide: Integrating Project Leadership, Artificial Intelligence, Simulation and Google Tools to Understand Regulation of Gene Expression with the Lac Operon and Lactase Gene
    Scientific leadership and current artificial intelligence (AI) skills are important skills to be included in the course curriculum. Together or individually, these skills can enhance knowledge,...

    Keywords: Resources @ HHMI - BioInteractivebiologymolecular biologygenomicsArtificial Intelligencegene expressionleadershipgroup worklactosegoogle toolsSeniorPhET SimulationLactase

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    Louse Genetics, Genomics, and Gene Function...Oh My!
    In this module, students will be investigating a louse gene with an unknown function to determine if it might be important in the evolution of the louse ecomorphs.

    Keywords: parasitesgenomicsgene sequence analysisFunctional Genomics

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    Neochromosomes: Creating transcriptional units with yeast Golden Gate assembly
    This resource is a series of protocols using the yeast Golden Gate (yGG) method as developed by Neta Agmon and Leslie Mitchell in Jef Boeke’s lab to assemble a functional yeast gene with...
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    Understanding Gene Prediction Programs
    Introduces students to the key biological concepts underlying computational gene prediction. Outcomes include ability to analyze and evaluate output of gene prediction programs, and reflect on...

    Keywords: Genome annotationSEA-PHAGESgene predictiongenemarkcoding potentialcodon biassix frame translation

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    Module 6: Alternative Splicing
    This module explores how multiple different mRNAs and polypeptides can be encoded by the same gene. After completing this module students will be able to explain how alternative splicing of a gene...

    Keywords: geneticsdata visualizationmolecular biologygenomicsexonintronalternative splicingSimilarity searchesMessenger RNA

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    Teaching Notes for Implementation of Gene Expression in Stem Cells
    Teaching notes for implementing Data Nugget: Gene Expression in Stem Cells in a introductory biology lab.

    Keywords: Resources @ Data Nuggetsteaching notes

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    Deme 2.0
    This workbook simulates the population genetics of a single gene with two alleles. It can simultaneously model up to three local populations, which may differ in their selection coefficients.

    Keywords: population geneticsGenetic DriftNatural Selection

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    LEAGSEA
    How to perform Leading Edge Analysis in Gene Set Enrichment Analysis by Broad Institute

    Keywords: videosbioinformaticsgenomicsyoutubeLEAGSEAgene set enrichmentLeading Edge Analysis

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    Drug screening and cancer resistance: EGFR Activity
    This activity explores a specific gene (egfr) and its role in cancer. EGFR was introduced with the Gene Card Activities, researched throughout the semester, and then authentic image data of...

    Keywords: Resources @ HHMI - BioInteractivegenomicscancergenetic basis of diseasebiology of cells

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    Introduction to Genome Browser: What is a Gene?
    In this module, we will use a web-based visualization tool called a Genome Browser to explore the structure of a eukaryotic gene, and obtain a basic understanding of how this information is...
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    Lesson VI - The Community Science Project
    Genome Solver's Community Science Project was developed as a way to use the skills taught in the previous lessons. We're asking members of the community to provide instances of potential phage...

    Keywords: Bioinformatics EducationBioinformatics and Genomics

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    GEA Introductory lesson on RNA-Seq
    This RNA-Seq lesson uses the CyVerse VICE Platform and Jupyter notebooks to examine the expression of the leptin gene in samples from a mouse experimental design evaluating diet (high-fat vs....

    Keywords: data sciencebioinformaticsGenome BrowserRNAseqhigh throughput sequencingmRNAAlignmentNCBI Sequence Read Archive

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    Evolution Through Natural Selection
    This Excel workbook simulates the population genetics of a single gene with two alleles, allowing the user to set the initial allele frequencies and enter parameters for a variety of different...

    Keywords: population geneticsNatural Selection

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    Module 1: Introduction to the Genome Browser: What is a Gene?
    This lesson introduces the University of California Santa Cruz genome browser to students, walking them through some of the key features so that it can be used for analysis of gene structure.

    Keywords: geneticsbioinformaticsGenome BrowserSimilarity searchesExonsIntronsEvidence TrackStart CodonStop Codon

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    Sickle Cell Anemia using Nicholas’ Story
    The goal of this exercise is to introduce students to 3-D structures of biological molecules, visualize and manipulate them to understand their functions. The exercise also helps them see the...

    Keywords: Hemoglobinsickle cell diseaseMolecular Case Study

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    GSEAtheory
    Brief introduction to how gene set enrichment analysis works.

    Keywords: videosbioinformaticsgenomicsyoutubegsea

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    Bioinformatics: the Power of Computers in Biology – a Practical Guide
    This Practical Guide in the Bringing Bioinformatics into the Classroom series introduces simple bioinformatics approaches for database searching and sequence analysis.

    Keywords: NIBLSEGOBLET

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    Module 2: Transcription Part I: From DNA Sequence to Transcription Unit
    This module illustrates how a primary transcript (pre-mRNA) is synthesized using a DNA molecule as the template. Students will learn about the importance of the 5' and 3' regions of the gene for...

    Keywords: data visualizationmolecular biologybioinformaticsGenome BrowsergenomicsTranscription InitiationTranscription Start SiteTranscription Termination Signal

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    RNA-seq Analysis
    In this computer lab module, students learn how to process an RNA-seq data set to identify differentially expressed genes (DEGs). The samples for this data set were collected from yeast cells...

    Keywords: LabRNAsequencingUndergraduateNIBLSEincubatorsRNAseqInstructional SettingAudience LevelActivity LengthMore than 1 hourC4. Bioinformatics toolsC5. Data retrievalReviewed at NIBLSEdifferentially expressed genes

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