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GENI-ACT allows collaborative genome annotation. Researchers or students can collectively suggest changes to an existing genome with supporting evidence. Changes can be ported back to genbank by exporting to a sequin file format.

GENI-ACT also has ported the education components from IMG-ACT. Teachers can assign students work to be completed in a lab notebook that is integrated with the classroom.

GENI-ACT is the next generation of software to annotate bacterial genomes and republish sequin files to NCBI Genbank.

The site automatically pulls text-based genbank files from NCBI FTP and converts them into an indexed binary form that can be easily searched and queried. These files are stored at The site also uses a three-tier architecture with a load-balancer, server nodes and dedicated database server.

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  2. Arshinoff BI, Suen G, Just EM, Merchant SM, Kibbe WA, Chisholm RL, Welch RD. Xanthusbase: adapting wikipedia principles to a model organism database. Nucleic Acids Res. 2007;35:D422-D426.
  3. Pratt-Szeliga PC, Skewes AD, Yan J , Welch LG, Welch RD. Xanthusbase after five years expands to become Openmods. Nucleic acids research 40 (D1), D1288-D1294



Bob Sheehy

Radford University