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  • Created 26 Jan 2015

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

Innate and adaptive defense mechanisms protect the respiratory system from attack by microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the mucosal innate defense of the human upper airway. Utilizing immunofluorescent and live cell imaging techniques in polarized primary human sinonasal cells, we demonstrate that T2R38 is expressed in human upper respiratory epithelium and is activated in response to acyl-homoserine lactone quorum-sensing molecules secreted by Pseudomonas aeruginosa and other gram-negative bacteria. Receptor activation regulates calcium-dependent NO production, resulting in stimulation of mucociliary clearance and direct antibacterial effects. Moreover, common polymorphisms of the TAS2R38 gene were linked to significant differences in the ability of upper respiratory cells to clear and kill bacteria. Lastly, TAS2R38 genotype correlated with human sinonasal gram-negative bacterial infection. These data suggest that T2R38 is an upper airway sentinel in innate defense and that genetic variation contributes to individual differences in susceptibility to respiratory infection.

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Hayley Orndorf onto Resources Using Populus

Mini-poster on Lotka-Volterra competition model

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Alison N Hale onto Populus mini-posters

Mini-poster on selection at a diallelic locus model

Created by Bob Sheehy

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Alison N Hale onto Populus mini-posters

Mini-poster on selection at a diallelic locus model

Created by Jeremy Seto

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Alison N Hale onto Populus mini-posters

Mini-poster on inbreeding model

Created by Alison Hale

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Alison N Hale onto Populus mini-posters

Summary of feedback from Google survey

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Exploring the Lotka-Volterra Competition Model using Two Species of Parasitoid Wasps

This lab activity is published by ESA in Teaching Issues and Experiments in Ecology (TIEE).

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Calculating Fitness

Exercise on calculating fitness and selection coefficients.

Created by Bob Sheehy at Radford University

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Population genetics simulation program

Created by Bob Sheehy at Radford University

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